Upregulation of Adhesion Molecule Expression on Endothelial Cells by Anti-DNA Autoantibodies in Systemic Lupus Erythematosus
✍ Scribed by Kar Neng Lai; Joseph C.K. Leung; Ka Bik Lai; Kong Chiu Wong; Christopher K.W. Lai
- Book ID
- 112240905
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 183 KB
- Volume
- 81
- Category
- Article
- ISSN
- 1090-2341
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## Abstract ## Objective To determine whether anti–endothelial cell autoantibodies (AECAs) from systemic lupus erythematosus (SLE) patients with the antiphospholipid syndrome are involved in the initial endothelial cell (EC) membrane perturbation effect that is postulated to provide a target for a
Shedding of cell-surface antigens that react with anti-lymphocyte autoantibodies in systemic lupus erythematosus (SLE) is well-recognized, but the nature of such molecules is unknown. The present investigation demonstrates the rapid shedding of three IgG antibody target molecules of Mr 55,000, 37,00