Update on sequential isologous rat organ transplantation: Pancreaticoduodenal and kidney transplantations

✍ Scribed by Sun Lee; Yuqin Wang; Lan Mao; Charles Cho; Sung Kim; Tatum Tarin; Dong-Heon Kim; Giuseppe Mazzoni; Marilena Fazi; Masumi Nozawa; Donna Lee; Bantayehu Sileshi; William Wei; Ada Lentini; Chang H. Yoo; Tyler Youngkin; Paul Wolf; Milbhor D'Silva; Ruben F. Gittes

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 507 KB
• Volume: 19
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/(sici)1098-2752(1999)19:2<83::aid-micr8>3.0.co;2-v

✦ Synopsis

This periodic report includes intermittent results of consecutive pancreaticoduodenal (Pd) and kidney (Kt) transplants in inbred rats and results on double kidney transplants that did not follow sequential transplant protocol. Eight 24-month-old Lewis pancreas, kidney, and aorta served histological controls showing normal histological architecture with no atherosclerosis developed in the aorta. Thirty-four month old pancreas and thirty-two month old kidneys, which resided in young hosts for at least three occasions, appeared as youthful Pd and Kt grafts. They show normal histological appear-ance for more than the expected life span of a Lewis rat. The fact that not only pancreases but also kidneys outlived their host leads to the study of other different organs' viability as aged valuable grafts. Nevertheless, the threats by the development of atherosclerosis in graft-associated aortas resulted in slow progression of the follow-ups.