Up-Regulation of Keratinocyte Growth Factor and Receptor: A Possible Mechanism of Action of Phenytoin in Wound Healing
โ Scribed by Swarga Jyoti Das; Irwin Olsen
- Book ID
- 115587700
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 138 KB
- Volume
- 282
- Category
- Article
- ISSN
- 0006-291X
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We have previously described the mitogenic and wound-healing properties of keratinocyte-conditioned medium (KCM). In this study we investigated the eect of KCM on the activation of second messenger systems and the expression of proto-oncogene in cultured human skin ยฎbroblasts. We also present a part
Transformed keratinocytes (SCC-4, SCC-15, SCC-12F2, SVK14) or normal keratinocytes which differ in their differentiation programme were used to study the regulation of EGF-receptor expression. The capacity of the cells to differentiate was modulated by changing the extracellular calcium concentratio