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Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration

✍ Scribed by Toyoko Arimoto; Guoying Bing


Book ID
117688486
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
414 KB
Volume
12
Category
Article
ISSN
0969-9961

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Amphotericin B potentiates the activatio
✍ Vladimir Trajkovic; Milos Markovic; Tatjana Samardzic; Djordje J. Miljkovic; Dus πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

## Abstract Because the neurotoxic effects of the antifungal drug amphotericin B (AMB) closely resemble those ascribed to the highly reactive gaseous free radical nitric oxide (NO), we investigated the effect of AMB on NO production in rodent astrocytes. AMB caused a dose‐dependent increase of NO g