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Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist

✍ Scribed by Murielle Rinaldi-Carmona; Monsif Bouaboula; Christian Congy; Florence Oury-Donat; Jacques Simiand; David Shire; Pierre Casellas; Philippe Soubrié; Jean-Claude Brelière; Gérard Le Fur


Book ID
113398443
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
739 KB
Volume
246
Category
Article
ISSN
0922-4106

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Rapid synthesis of [18F]SR46349B, a pote
✍ Pingzhong Tan; Joanna S. Fowler; Yu-Shin Ding; David J. Schlyer 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 483 KB

## Abstract F‐18 labeled SR46349B, a highly potent and selective 5‐HT~2~ receptor antagonist, was synthesized as a potential radioligand for PET studies of brain 5‐HT~2~ receptors. Nucleophilic aromatic substitution of __trans__‐1‐(2‐nitrophenyl)‐3‐(4‐methoxymethoxyphenyl)‐2‐propenone (10) with NCA