Rapid synthesis of [18F]SR46349B, a pote
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Pingzhong Tan; Joanna S. Fowler; Yu-Shin Ding; David J. Schlyer
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Article
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1995
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John Wiley and Sons
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French
⚖ 483 KB
## Abstract F‐18 labeled SR46349B, a highly potent and selective 5‐HT~2~ receptor antagonist, was synthesized as a potential radioligand for PET studies of brain 5‐HT~2~ receptors. Nucleophilic aromatic substitution of __trans__‐1‐(2‐nitrophenyl)‐3‐(4‐methoxymethoxyphenyl)‐2‐propenone (10) with NCA