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Unveiling the Membrane-Binding Properties of N-Terminal and C-Terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies

✍ Scribed by Ding, Bei; Glukhova, Alisa; Tesmer, John J.G.; Chen, Zhan


Book ID
123542494
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
97 KB
Volume
106
Category
Article
ISSN
0006-3495

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## Abstract Transmembrane domains (TMDs) of G‐protein coupled receptors (GPCRs) have very low water solubility and often aggregate during purification and biophysical investigations. To circumvent this problem many laboratories add oligolysines to the __N__‐ and __C__‐termini of peptides that corre