Unusual β-sheet periodicity in small cyclic peptides
✍ Scribed by Gibbs, Alan C.; Kondejewski, Leslie H.; Gronwald, Wolfram; Nip, Alex M.; Hodges, Robert S.; Sykes, Brian D.; Wishart, David S.
- Book ID
- 109964763
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 631 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1072-8368
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A 20-membered cyclic peptide disulfide Boc-C ys-Val-Aib-Ma-Leu-C ys-NHMe I I S S has been synthesized as a conformational model for disulfide loops of limited ring size. 'H-nmr studies at 270 MHz establish the presence of three intramolecular hydrogen bonds involving the Leu, Val, and methylamide NH
## Abstract In the present paper we describe the synthesis, purification, and single crystal x‐ray analysis of the cyclic pentapeptide __cyclo__‐(L‐Pro‐L‐Pro‐L‐Phe‐β‐Ala‐β‐Ala). The peptide was synthesized by classical solution methods and the cyclization of the free pentapeptide was accomplished i