Unusual T- and T/NK- cell non-Hodgkin's lymphoma of the larynx: A diagnostic challenge for clinicians and pathologists

✍ Scribed by Johnny S. W. Mok; Martin Wai Pak; K. F. Chan; John Chow; C. A. van Hasselt

• Book ID: 102235882
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 170 KB
• Volume: 23
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.1088

✦ Synopsis

Background:

Lymphomas of t-cell and t/natural killer (t/nk)-cell types rarely involve the larynx. early symptoms are subtle and nonspecific, and confirmation of the diagnosis is often difficult. because of the rarity of this disease entity, the optimal management remains controversial.

Methods:

The case records of patients with the diagnosis of lymphoma involving the larynx were retrospectively reviewed. details of the pathologic condition, the difficulties in diagnosis, and treatment were presented.

Results:

One case of t-cell lymphoma (lennert's lymphoma subtype) and two cases of t/nk-cell lymphomas involving the larynx were presented. the diagnoses were all difficult to establish. all three patients received either multiagent chemotherapy or radiotherapy as the first-line treatment. they all died of the disease within 32 months of diagnosis.

Conclusions:

T- and t/nk-cell non-hodgkin's lymphoma of the larynx is a diagnostic challenge for clinicians and pathologists. conventional chemotherapy or radiotherapy has not been effective. a more aggressive therapy should be considered.