✦ LIBER ✦

Unusual skin rash following withdrawal of oral 6-mercaptopurine in children with leukemia

✍ Scribed by Kirk, Judy A. ;Rogers, Maureen ;Menser, Margaret A. ;Bergin, Mary ;Dalla-Pozza, Luciano ;Stevens, Michael M.

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 319 KB
Volume: 15
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950150512

No coin nor oath required. For personal study only.

✦ Synopsis

Sixteen episodes of a distinctive, papular rash occurred in eight patients following withdrawal of 6-mercaptopurine (6MP) and methotrexate (MTX) used as maintenance therapy for acute lymphoblastic leukemia (ALL). The rash also developed in one of the eight patients when only 6MP was discontinued. The eruption occurred mainly on the face, and in this site resembled the perioral dermatitis seen following withdrawal of topical fluorinated steroids. The rash generally began within 3 weeks of stopping 6MP and lasted 3 to 4 weeks. It failed to improve with the use of topical corticosteroid. We conclude that this rash is caused by the withdrawal of oral 6MP.

📜 SIMILAR VOLUMES

Disposition of oral methotrexate in chil

Disposition of oral methotrexate in children with acute lymphoblastic leukemia and its relation to 6-mercaptopurine pharmacokinetics

✍ Koren, Gideon ;Solh, Hassan ;Klein, Julia ;Soldin, Stephen J. ;Greenberg, Mark 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 444 KB

We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (

Pharmacokinetics and metabolism of thiop

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine

✍ Norbert Erb; Dörthe O. Harms; Gritta Janka-Schaub 📂 Article 📅 1998 🏛 Springer 🌐 English ⚖ 195 KB

Intraindividual variation in 6-mercaptop

Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia

✍ P. Lafolie; S. Hayder; O. Björk; C. Peterson 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 318 KB

Intraindividual variation in 6-mercaptopurine (6-MP) kinetics has been little studied. It has now been examined in 18 children with acute lymphoblastic leukaemia (ALL). On 2 to 4 occasions in each patient drug concentrations in plasma and red cells were followed for 4 h after administration by means