Antigenically heterogeneous strains and new variants of influenza A viruses, both A (H3N2) and (H1N1) subtypes, as well as influenza B strains were detected in Italy in a period, between 1984-1987, characterized by a moderate degree of influenza activity. Each year the evaluation, by SRH technique,
โฆ LIBER โฆ
Unusual restriction of a proliferative line reacting with influenza A and B viruses
โ Scribed by Ghyslaine Sterkers; Claude Hannoun; Jean Paul Levy
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 684 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0093-7711
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โฆ Synopsis
A human T-cell line, B3, has been obtained by cloning spleen cells at limiting dilutions in the presence of influenza-A-virus-infected autologous cells. B3 cells were OKT 3+4+8 -, E rosetting +, Sig-and were HLA-DR (+) after stimulation and HLA-DR (-) when resting. They proliferate specifically in the presence of influenza-virus-infected cells. Remarkable is that (a) the proliferation was obtained with viruses of both A and B types and (b) only autologous cells seem to be able to present the viral antigen to B3 cells.
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