Unusual reactivity of sulfahydantoins in the Mitsunobu reaction
β Scribed by Georges Dewynter; Sophie Ubaldi; Normand Voyer; Loic Toupet
- Book ID
- 108387046
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 208 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Treatment of benzoic acid with triphenylphosphine and diisopropyl azodicarboxylate in THF or acetonitrile, results in the formation of benzoic anhydride. A significant solvent effect was observed for this reaction. Anhydride formation did not occur however with the more acidic pnitrobenzoic acid. Re
The Mitsunobu reaction Β± the nucleophilic substitution of an alcoholic hydroxyl group mediated by the redox system trialkylphosphine/dialkyl azodicarobxylate Β± is widely used in the chemistry of biologically active compounds. The paper deals with applications of the Mitsunobu reaction in amino acid