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Unusual peptide bond cleavage reactions during acidolytic deprotection reactions

✍ Scribed by Spencer, Jeffrey R.; Delaet, Nancy G. J.; Toy-Palmer, Anna; Antonenko, Valery V.; Goodman, Murray


Book ID
121442503
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
470 KB
Volume
58
Category
Article
ISSN
0022-3263

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## Abstract Unusual TFA catalyzed cleavage reaction is reported for peptide containing pipecolic acid residues. Although the use of TFA under standard cleavage conditions is sufficiently mild to prevent degradation of the desired products, the amide bond between consecutive pipecolic acid residues