Unusual pattern of gastric and hepatic infiltration in an infant with acute monocytic leukemia
β Scribed by U. Kontny; P. Gutjahr; R. Schumacher
- Book ID
- 105438417
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 492 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0301-0449
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## Abstract More than 30 fusions involving the __MLL__ gene at 11q23 have been reported in acute myeloid leukemia (AML). Some of these chimeras are rather common, such as __MLL/MLLT3__(__AF9__), but many are quite rare, with some, for example, __MLL/GRAF__, described only in a single case. The __ML
Chromosomal analysis of acute monocytic leukemia cells in a female infant revealed a t(6;11)(q27;q23) translocation. Southern blot analysis with a cDNA probe of the MLL gene at chromosome band 11q23 indicated that the breakpoint was in an 8.3-kb BamHI fragment that contained exons 5-11 of the MLL ge