✦ LIBER ✦
Unusual hydroxy-γ-sultone byproducts of steroid 21-methanesulfonylation. An efficient synthesis of mometasone 17-furoate (Sch 32088)
✍ Scribed by Richard W. Draper; Bin Hu; Andrew T. McPhail; Mohindar S. Puar; Eugene J. Vater; Lois Weber
- Book ID
- 104209069
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 800 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
An efficient two stage synthesis of the steroid anti-inflammatory agent mometasone 17furoate (Sch 32088) 4 from 17ct,21-dihydroxy-16ct-methyl-9~, 1 l[~-oxidopregna-1,4-diene-3,20-dione e is described and the structures of unusual 6-hydroxy-¥-sultone byproducts of 4-dimethylaminopyridine catalyzed methanesulfonylation of 21-hydroxy-20-ketosteroids are deduced.