Unusual clinical courses of adult T-cell leukemia in siblings

✍ Scribed by Fumio Kawano; Hiroyukl Tsuda; Kazunari Yamaguchi; Hiromichi Nishimura; Isao Sanada; Hiromitsu Matsuzaki; Masao Ishii; Kiyoshi Takatsuki

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 419 KB
• Volume: 54
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19840701)54:1<131::aid-cncr2820540126>3.0.co;2-q

✦ Synopsis

Two siblings who developed adult T-cell leukemia (ATL) with unusual clinical courses are presented. The brother showed spontaneous remissions at the beginning stage of the disease of 6 years' duration, and the sister remains free of complaints for 6 years without chemotherapy. The patients and 2 of 12 healthy members of their family examined had serum antibodies against ATLassociated antigens (ATLA). The expression of ATLA was observed in the cultured lymphocytes from the patients and one of the family members.