Unusual amino acids VIII. Asymmetric hydrogenation of some heteroaryl-N-CBZ and N-BOC aminocinnamic acid derivatives

Unusual amino acids VI. Substituted aryl

Unusual amino acids VI. Substituted arylamino acids by asymmetric hydrogenation of N-Cbz and N-Boc protected dehydroamino acid derivatives

✍ H. W. Krause; H.-J. Kreuzfeld; U. Schmidt; CH Döbler; M. Michalik; S. Taudien; C 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 997 KB

Substituted N-Cbz and N-Boc protected arylamino acrylic acids and esters have been prepared and used in asymmetric hydrogenations catalyzed by PROPRAPHOS-Rh. Stereoselectivities > 90% ee could be achieved, the rate of which is dependent on the position of the substituent in the aromatic ring. The N-