Untersuchungen über die Coronarwirksamkeit des Adenosin und der Adeninnucleotide sowie ihre Beeinflussung durch zwei Substanzen mit starker Coronarwirkung
✍ Scribed by J. Scholtholt; W. D. Bussmann; W. Lochner
- Publisher
- Springer
- Year
- 1965
- Tongue
- English
- Weight
- 798 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0031-6768
No coin nor oath required. For personal study only.
✦ Synopsis
The effects on coronary flow of infusions of adenosine and adenosintriphosphate were studied in dogs and isolated guineapig hearts. Intracoronary infusions of equimolar doses of ASN and ATP in dogs produced equal effects. In isolated hearts the following relation of effects was found: ASN: AMP: ADP: ATP = 1:0.76:1:1.
The effects of intracoronary infusions of ASN and ATP in dogs were not influenced by persantin. In isolated guinea-pig hearts these substances showed slightly increased effects (1.7--1.9 times) during the action of persantin. The effects of intravenous infusions of ASN and ATP were potentiated by the factor 32 and 52 during the course of our experiments. This potentiation is caused solely by the blood and can be explained satisfactorily by the inhibited permeation of ASN through the membranes of erythrocytes as a result of the action of persantin.
Intensain did not influence the effects of ASN, AMP and ATP in isolated hearts. The effects were neither potentiated nor prolonged. These findings do not support the hypothesis that adenosine has a function as a transmitter substance in the regulation of coronary blood flow.