✍ Scribed by Rohwedder, H. -J. ;Simon, C. ;K�bler, W. ;Hohenauer, M.
No coin nor oath required. For personal study only.
The plasma activity of nalidixic acid was determined in 48 children of different ages and 10 adults after oral administration.
The apparent distribution volumes and the values of the elimination constants and invasion constants were calculated in 18 children and 10 adults after single oral doses. The apparent distribution volumes showed no difference between young children and adults, values varying belbween 19.5 and 26.6~ of body weight. Invasion and elimination of the substance was significantly delayed in the newborn and in the first 3 months of life. Calculation of the cited pharmacokinetic values was impossible in 2 prematures and in 8 newborn due to the extreme delay in elimination resulting in high plasma levels for more than 8 hrs after ingestion. In newborn and infants doses of 20 mg/kg three times daily may cause unusually high plasma, levels due to accumulation of the substance as a result of delayed elimination. Nalidixic acid should preferably not be given to infants under 3 months at all-and if absolutely necessary only in clinical treatment and in doses of 10--12 mg/kg three times daily. Toxic reactions may be: acute elevation of intracrani~l pressure, asphyxia, tachydyspnea, metabolic acidosis and circulatory collapse.
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