Unsymmetrically Substituted Furoxans, XIV. Synthesis and Structure of a Trimer of the Furoxan System with High Vasodilator and Platelet Antiaggregatory Activity

✍ Scribed by Gasco, Andrea Marcello ;Di Stilo, Antonella ;Fruttero, Roberta ;Sorba, Giovanni ;Gasco, Alberto ;Sabatino, Piera

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 313 KB
• Volume: 1993
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.199319930172

✦ Synopsis

Abstract

The synthesis and structure of a trimer 5 of the furoxan system are reported. The probable origin of this derivative is the dimerization of the intermediate 4‐phenyl‐3‐furoxancarbonitrile oxide (4) obtained by decomposition of the corresponding nitrolic acid 3. The title compound shows a high level of activity as vasodilator and inhibitor of platelet aggregation.