Unsymmetrically substituted furoxans. Part 19. Methyl and phenylfuroxansulfonic acids and related sulfonamides

✍ Scribed by Konstantin Chegaev; Barbara Rolando; Stefano Guglielmo; Roberta Fruttero; Alberto Gasco

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 117 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.149

✦ Synopsis

Abstract

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Synthesis, structural characterization, and acid dissociation constants (p__K__~a~) of a series of methyl‐ and phenyl‐substituted furoxansulfonic acids and related sulfonamide derivatives, as well as their furazan analogues are described. The ability of furoxans to dilate rat aorta strips precontracted with phenylephrine is reported as an example of their NO‐dependent pharmacological properties. J. Heterocyclic Chem., (2009).