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Unsymmetrical covariance processing of COSY or TOCSY and HSQC NMR data to obtain the equivalent of HSQC-COSY or HSQC-TOCSY spectra

✍ Scribed by Kirill A. Blinov; Nicolay I. Larin; Antony J. Williams; Kent A. Mills; Gary E. Martin

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 79 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430124

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✦ Synopsis

Abstract

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Artifacts observed in the indirect covariance NMR spectrum of HSQC‐TOCSY data have recently been analyzed and a method for their elimination proposed. More recently, unsymmetrical covariance processing has been applied HSQC and HMBC spectral data to afford long‐range carbon‐carbon correlation information equivalent to that obtained from n, 1‐, 1, n‐ and m,n‐ADEQUATE spectra. We now wish to describe the results obtained through the application of unsymmetrical covariance processing of HSQC and COSY or TOCSY data, which affords the equivalent of HSQC‐COSY and HSQC‐TOCSY data in a fraction of the time required to record these spectra directly and with considerably higher sensitivity.

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## Abstract We have recently demonstrated that unsymmetrical indirect covariance NMR methods can be used to mathematically calculate the equivalent of low sensitivity, hyphenated NMR experiments by combining data from a pair of higher sensitivity experiments. The present report demonstrates the app