Unsuccessful trial of gene replacement in arginase deficiency

✍ Scribed by H. G. Terheggen; A. Lowenthal; F. Lavinha; J. P. Colombo; S. Rogers

• Book ID: 104780912
• Publisher: Springer
• Year: 1975
• Tongue: English
• Weight: 168 KB
• Volume: 119
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00464689

✦ Synopsis

Abs'tract. The Shope virus following cutaneous inoculation produces skin papillomas in rabbits and induces a virus-coded arginase in the squameons epithelium of these papillomas. The only discernible effect of the virus inoculated intravenously in rabbits and other animals was a decrease of the serum arginine concentration. Intravenous injection in 3 hyperargininemie patients, however, did not influence the underlying metabolic disease.