Unscheduled DNA synthesis correlated to alkylation of hemoglobin in individuals occupationally exposed to propylene oxide

✍ Scribed by Ronald W. Pero; Siv Osterman-Golkar; Benkt Högstedt

• Book ID: 104627829
• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 395 KB
• Volume: 1
• Category: Article
• ISSN: 0742-2091
• DOI: 10.1007/bf00118195

✦ Synopsis

Exposure to propylene oxide was determined previously by the degree of alkylation of hemoglobin measured on the histidine residue as N-3-(2-hydroxypropyl) histidine, using blood samples from 8 propylene oxide-exposed employees and 13 unexposed referents. Mononuclear leukocytes isolated from the same blood samples were used to quantify DNA repair proficiency following an in vitro challenge with the carcinogen, N-acetoxy-2-acetylaminofluorene. Decreases in the DNA repair profciency index correlated significantly to in vivo exposure levels to propylene oxide (r = -0.64, p < 0.03). These data suggest a possible short-term biological assay for monitoring the in vivo genotoxic effects of propylene oxide exposure in the human population.