Unsaturated Oxo−Nitriles: Stereoselective, Chelation-Controlled Conjugate Additions
✍ Scribed by Fleming, Fraser F.; Guo, Jianping; Wang, Qunzhao; Weaver, Douglas
- Book ID
- 127327084
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 146 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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Chelation-controlled conjugate addition of Grignard reagents to g-hydroxyalkynenitriles stereoselectively generates tri-and tetra-substituted alkenenitriles. t-BuMgCl-initiated deprotonation of hydroxyalkynenitriles followed by addition of a second Grignard reagents triggers a facile conjugate addit