Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages

Regulatory role of Sirt1 on the gene exp

Regulatory role of Sirt1 on the gene expression of fatty acid-binding protein 3 in cultured porcine adipocytes

✍ Ti Z. Shan; Yang Ren; Ting Wu; Chen X. Liu; Yi Z. Wang 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 258 KB

## Abstract To investigate whether Sirt1 could modulate fatty acid‐binding protein 3 (FABP3), we treated porcine adipocytes either with the Sirt1 inhibitor nicotinamide (NAM), with the Sirt1 activator resveratrol (RES), or by knockdown of Sirt1 by Sirt1‐siRNA. NAM or knockdown with Sirt1‐siRNA sign