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Unsaturated amino-acid residues as probes for the conformation of polypeptides in solution

✍ Scribed by Osvaldo Pieroni; Adriano Fissi; Giorgio Montagnoli; Francesco Ciardelli

Publisher
Wiley (John Wiley & Sons)
Year
1977
Tongue
English
Weight
479 KB
Volume
16
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Acetyl‐(dehydro‐Phe) and acetyl‐bis(dehydro‐Phe) groups have been attached to the ε‐amino group of the lysine residues of the copolymer poly(Glu^92^Lys^8^) by reacting this last with acetyl‐(dehydro‐Phe)‐azlactone and acetyl‐bis(dehydro‐Phe)‐azlactone, respectively.

In the latter case induced CD is observed between 250 and 330 nm, due to the relative dissymmetric disposition of the two dehydro‐Phe groups under the chiral field of the polypeptide chain.

pH dependence of the induced CD, observed for the copolymer and lacking in the lowmolecular‐weight structural model, is related to the α‐helical and random coiled conformation of the polypeptide chain.

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The author has brought to our attention the following revision for Table II of the article listed above, published in Biopolymers 2008, 90(2):138-150. See the revised table shown on the following page.