✦ LIBER ✦

Unrelatedness of factor VIII-derived non-A/non-B hepatitis and hepatitis B virus

✍ Scribed by H. A. Fields; C. L. Davis; H. S. Margolis; K. A. McCaustland; C. M. Wheeler; J. E. Maynard; D. W. Bradley; M. Bernlnger; M. Hammer; N. Nath

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 407 KB
Volume: 11
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890110108

No coin nor oath required. For personal study only.

✦ Synopsis

A DNA hybridization assay was used to detect hepatitis B virus (HBV)-specific DNA sequences in extracted sera obtained from chimpanzees infected with HBV, hepatitis A virus (HAV), and a factor VIII-derived non-A/non-B (NANB) agent. The results did not reveal any HBV-DNA homology with sera obtained from animals infected with HAV or factor VIII-derived NANB. Sera obtained from two HBV-infected chimpanzees demonstrated that HBV-specific DNA could be detected during the acute phase of the disease. In addition, an HBV-specific DNA-dependent DNA polymerase assay did not demonstrate any statistically significant activity in 12 of 12 NANB acute-phase specimens or in 6 of 6 NANB chronic-phase specimens. These results suggest that the factor VIII-derived NANB agent is unrelated to HBV.

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