𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Unrelated clonal chromosomal aberrations in carcinomas of the oral cavity

✍ Scribed by Dr. Yuesheng Jin; Sverre Heim; Nils Mandahl; Anders Biörklund; Johan Wennerberg; Felix Mitelman

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
451 KB
Volume
1
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Short‐term cultures from 12 oral squamous cell carcinomas were cytogenetically investigated. A normal karyotype was found in 3 tumors, 2 of which had many nonclonal changes. Clonal chromosome abnormalities were detected in the remaining 9 cases, in 6 of them in the form of 2 or 3 abnormal clones. In 5 cases the different clones were cytogenetically unrelated, suggesting a multiclonal origin. Numerous additional nonclonal changes were present in 4 of the 9 tumors with clonal aberrations. None of the structural aberrations, clonal or nonclonal, were found in more than one case; nor did any of the rearrangements correspond to cancer‐associated aberrations known from other tumors. The aberration breakpoints of the present series and of a previously reported tongue cancer clustered to bands 1p32, 1p22, 1p11, 1q21, 1q23, 1q25, 1q32, 1q42, 1q44, 2q31, 3p11, 4q35, 7p22, 11p15, 11q13, 12q24, and 17q25.

📜 SIMILAR VOLUMES

Histopathologic parameters in the evalua
Histopathologic parameters in the evaluation of T1 squamous cell carcinomas of the oral cavity
✍ Troels Bundgaard; Kristian Rossen; Søren D. Henriksen; Samih Charabi; Helmer Søg 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## Background: Prognostic indicators that could assist in a more precise selection of patients with small oral carcinomas for differentiated therapy would be valuable. a significant fraction of patients with stage i disease have a relatively poor prognosis despite the small size of the tumor, but i

Endoglin (CD105) expression in squamous
Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity
✍ Ronald Schimming; Dieter Marmé 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

## Abstract ## Background Increasing evidence suggests that endoglin (CD105) is a new powerful marker of neovascularization in solid malignancies. To explain the rating of CD105 expression in 51 squamous cell carcinoma of the oral cavity (SCCOC) we analyzed CD105 expression in tumor tissue and adj

A comparison of published head and neck
A comparison of published head and neck stage groupings in carcinomas of the oral cavity
✍ Patti A. Groome; Karleen Schulze; Morten Boysen; Stephen F. Hall; William J. Mac 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## Background: The combination of t, n, and m classifications into stage groupings is meant to facilitate a number of activities, including the estimation of prognosis and the comparison of therapeutic interventions among similar groups of cases. we tested the uicc/ajcc 5th edition stage grouping a