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Unravelling the complex genetics of cleft lip in the mouse model

✍ Scribed by Diana M. Juriloff; Muriel J. Harris; Carolyn J. Brown


Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
939 KB
Volume
12
Category
Article
ISSN
0938-8990

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## Abstract Nonsyndromic cleft lip and palate (CLP) is among the most common human birth defects. Transmission patterns suggest that the causes are β€œmultifactorial” combinations of genetic and nongenetic factors, mostly distinct from those causing cleft secondary palate (CP). The major etiological

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Orientals consisting of Japanese, Chinese, Koreans, and Filipinos are clearly at higher risk for cleft lip with or without cleft palate [CL(P)] than whites, Puerto Ricans, and Hawaiians/part-Hawaiians in Hawaii. Using the model of diallele cross, CL(P) incidences in incrosses and outcrosses involvin