Unraveling diffusion constants in biological tissue by combining Carr-Purcell-Meiboom-Gill imaging and pulsed field gradient NMR
✍ Scribed by Dagmar van Dusschoten; Chrit T. W. Moonen; P. Adrie de Jager; Henk Van As
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 883 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A diffusion‐weighted multi‐spin‐echo pulse sequence is presented, which allows for simultaneous measurement of T~2~, the fractional amplitude, and the diffusion constant of different fractions. Monte Carlo simulations demonstrate an improvement of this sequence with respect to the accuracy of diffusion constant and fractional amplitude for slow exchange. Examples are shown for a simple phantom containing two fractions. In addition, experiments on cat brain in healthy condition and following occlusion of the middle cerebral artery show that the fractional amplitude and the diffusion constant of cerebral spinal fluid and normal brain tissue can be analyzed within each pixel with acceptable accuracy.