𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Unnatural amino acids as probes of protein structure and function

✍ Scribed by Dennis A Dougherty

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
291 KB
Volume
4
Category
Article
ISSN
1367-5931

No coin nor oath required. For personal study only.

✦ Synopsis

Nonsense suppression methodology, for incorporating unnatural amino acids into proteins, has enabled a wide range of studies into protein structure and function using both in vitro and in vivo translation systems. Although methodological challenges remain, scores of unnatural amino acids have been employed that include both subtle and dramatic variants of the natural set. A number of insights that would not have been possible using conventional site-directed mutagenesis have been gained.

πŸ“œ SIMILAR VOLUMES

Molecular design of functional peptides
Molecular design of functional peptides by utilizing unnatural amino acids: Toward artificial and photofunctional protein
✍ Hitoshi Ishida; Masato Kyakuno; Shigero Oishi πŸ“‚ Article πŸ“… 2004 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 481 KB πŸ‘ 2 views

## Abstract Unnatural amino acids are effective as building blocks to design functional peptides from the following two points: (1) utilization of rigid unnatural amino acids for the incorporated peptides to control the conformation to appear the function, and (2) incorporation of functional and un

Amino Acids, Peptides and Proteins in Or
Amino Acids, Peptides and Proteins in Organic Chemistry (Origins and Synthesis of Amino Acids) || Synthesis of Unnatural/Nonproteinogenic α-Amino Acids
✍ Hughes, Andrew B. πŸ“‚ Article πŸ“… 2010 πŸ› Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German βš– 367 KB πŸ‘ 2 views

This is the first of five books in the *Amino Acids, Peptides and Proteins in Organic Synthesis* series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino

Probing protein structure by amino acid-
Probing protein structure by amino acid-specific covalent labeling and mass spectrometry
✍ Vanessa Leah Mendoza; Richard W. Vachet πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 649 KB

## Abstract For many years, amino acid‐specific covalent labeling has been a valuable tool to study protein structure and protein interactions, especially for systems that are difficult to study by other means. These covalent labeling methods typically map protein structure and interactions by meas