Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins

Epigenetic regulation of metallothionein

Epigenetic regulation of metallothionein-i gene expression: Differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins

✍ Sarmila Majumder; Huban Kutay; Jharna Datta; Dennis Summers; Samson T. Jacob; Ka 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

## Abstract Metallothioneins (MTs) are a group of cysteine‐rich stress response proteins that scavenge reactive oxygen species and heavy metals. Recently, we have shown that MT‐I promoter is methylated and suppressed in some solid and liquid tumors and can be robustly activated following treatment