Unlike β-endorphin, dynorphin1–13does not cause retrograde amnesia for shuttle avoidance or inhibitory avoidance learning in rats
✍ Scribed by Ivan Izquierdo; Marco A. M. R. Almeida; Vera R. Emiliano
- Book ID
- 104771476
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 322 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
Posttraining administration of the opioid peptides, fl-endorphin or the enkephalins, is known to cause retrograde amnesia for a variety of tasks in rats. The present paper studies the effect of the posttraining administration of dynorphinl 13 on retention of a step-down inhibitory avoidance task and of a shuttle avoidance task. For the purpose of comparison, the effect of human fl-endorphin was also studied. In confirmation of previous results, ~endorphin (1.0 or 10.0 ~tg/kg, IP) caused retrograde amnesia for the two tasks. Dynorphinl 13 had no effect at doses between 0.008-125.0 gg/kg IP or 1.25-125.0 ng/rat ICV in the inhibitory avoidance task, or at doses of 5.0, 25.0, or 125.0 gg/kg in the shuttle avoidance paradigm. These findings suggest that, in contrast to fl-endorphin, dynorphinl 13 may not be involved in memory regulation at the posttraining period in rats.