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Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

✍ Scribed by Paola Panina-Bordignon; Agnes Tan; Annemarie Termijtelen; Stefan Demotz; Giampietro Corradin; Antonio Lanzavecchia


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
510 KB
Volume
19
Category
Article
ISSN
0014-2980

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Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e