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Univalent immunotoxins containing ricin A (IT-A) and richin B chains (IT-B) synergize in killing target cells in vitro

✍ Scribed by E.S. Vitetta; J. Fulton; J.W. Uhr


Book ID
103624608
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
56 KB
Volume
7
Category
Article
ISSN
0192-0561

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Ricin A chain-containing immunotoxins (IT-As) specific for the human &ell antigen, CD22, were prepared from 4 monoclonal antibodies (MAbs) or their Fab' fragments: RFB4, HD6, UV22-I and UV22-2. The ITS were tested for their ability to kill cells from the Burkitt lymphoma line, Daudi, the pre-6cell l