Unique property of copper(I) chloride as a radical initiator as well as a Lewis acid: Application to CuCl-catalyzed aldol reaction of α,β-unsaturated ketones with Bu3SnH

✍ Scribed by Takashi Ooi; Kanae Doda; Daiki Sakai; Keiji Maruoka

• Book ID: 104260928
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 171 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00130-6

✦ Synopsis

Copper (I) chloride in combination with tributyltin hydride showed unique character as an initiator of certain radical reactions. Hydrostannation of or,B-unsaturated ketones with Bu3SnH was initiated by CuC1 and the resulting tin enolates underwent subsequent aldol reaction with aldehydes under the influence of CuCI as a Lewis acid catalyst.