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Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

✍ Scribed by Dr. Muthiah Manoharan; Dr. Akin Akinc; Dr. Rajendra K. Pandey; June Qin; Dr. Philipp Hadwiger; Dr. Matthias John; Kathy Mills; Dr. Klaus Charisse; Dr. Martin A. Maier; Dr. Lubomir Nechev; Emily M. Greene; Dr. Pradeep S. Pallan; Prof. Eriks Rozners; Dr. Kallanthottathil G. Rajeev; Prof. Martin Egli


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
793 KB
Volume
123
Category
Article
ISSN
0044-8249

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Synthesis and Structural Characterizatio
✍ Dr. Troels Bundgaard Jensen; Dr. Anna Pasternak; Dr. Andreas Stahl Madsen; Dr. M 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 471 KB 👁 1 views

## Abstract We describe the synthesis and binding properties of oligonucleotides that contain one or more 2′‐fluoro‐α‐L‐RNA thymine monomer(s). Incorporation of 2′‐fluoro‐α‐L‐RNA thymine into oligodeoxynucleotides decreased thermal binding stability slightly upon hybridization with complementary DN