Unique expression patterns of matrix metalloproteinases in regenerating newt limbs
โ Scribed by Tomoko Kato; Koyomi Miyazaki; Keiko Shimizu-Nishikawa; Kazuko Koshiba; Masanobu Obara; Hiromu K. Mishima; Katsutoshi Yoshizato
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 651 KB
- Volume
- 226
- Category
- Article
- ISSN
- 1058-8388
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One of the earliest events in limb regeneration is the extensive remodeling of the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are a family of matrix degrading enzymes that have been identified in both normal and disease states. Using RT-PCR and cDNA library screening, we have isola
The regenerative ability of limb stumps bearing partial circumferences of flank skin was tested in the newt, Notophthalmus viridescens. Skin dorsal to the lateral line of the flank was removed and used to replace 1/4, 112, or 314 of the skin of the upper forelimb. Grafts were placed at anterior, pos