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Unique DNA Binding Mode of the N-Terminal Zinc Finger of Transcription Factor Sp1 †

✍ Scribed by Yokono, Masanori; Saegusa, Nana; Matsushita, Keizo; Sugiura, Yukio


Book ID
125463415
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
173 KB
Volume
37
Category
Article
ISSN
0006-2960

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✍ Alia Al-Sarraj; Regina M. Day; Gerald Thiel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

## Abstract The transcription factors Sp1, Sp3, and Egr‐1 bind with their zinc finger DNA‐binding domains to GC‐rich sequences in the regulatory regions of their target genes. The similarity of the DNA‐binding sites of Sp1, Sp3, and Egr‐1 has triggered the hypothesis that they compete for the same