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Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung

✍ Scribed by Lewis, Christina C.; Aronow, Bruce; Hutton, John; Santeliz, Joanna; Dienger, Krista; Herman, Nancy; Finkelman, Fred D.; Wills-Karp, Marsha


Book ID
119282159
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
368 KB
Volume
123
Category
Article
ISSN
1097-6825

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## Abstract In Th1 and Th2 memory lymphocytes, the genes for the cytokines interleukin (IL)‐4 and interferon‐γ (IFN‐γ) are imprinted for expression upon restimulation. This cytokine memory is based on expression of the transcription factors T‐bet for IFN‐γ, and GATA‐3 for IL‐4, and epigenetic modif