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Uniparental inheritance of themitochondrialgene cytochrome b inPlasmodium falciparum

✍ Scribed by Alison M. Creasey; Lisa C. Ranford-Cartwright; Daphne J. Moore; Donald H. Williamson; Robert J. M. Wilson; David Walliker; Richard Carter

Book ID: 104716850
Publisher: Springer-Verlag
Year: 1993
Tongue: English
Weight: 760 KB
Volume: 23
Category: Article
ISSN: 0172-8083
DOI: 10.1007/bf00310900

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✦ Synopsis

The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite.

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