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Unimolecular Beacons for the Detection of DNA-Binding Proteins

โœ Scribed by Knoll, Eric; Heyduk, Tomasz


Book ID
126902797
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
220 KB
Volume
76
Category
Article
ISSN
0003-2700

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Aptamer Beacons for the Direct Detection
โœ Nobuko Hamaguchi; Andrew Ellington; Martin Stanton ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 148 KB

We have designed a new class of molecules, which we term aptamer beacons, for detecting a wide range of ligands. Similar to molecular beacons, aptamer beacons can adopt two or more conformations, one of which allows ligand binding. A fluorescence-quenching pair is used to report changes in conformat