Cardinal symptoms of Parkinson's disease (PD) respond well to treatment with levodopa and deep brain stimulation (DBS) of the subthalamic nucleus (STN). However, it has remained unclear whether levodopa and STN-DBS have differential effects on bradykinesia. We investigated 8 PD-patients with STN-ele
Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease
β Scribed by Samer D. Tabbal; Mwiza Ushe; Jonathan W. Mink; Fredy J. Revilla; Angie R. Wernle; Minna Hong; Morvarid Karimi; Joel S. Perlmutter
- Book ID
- 116459306
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 502 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0014-4886
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## Abstract The purpose of this study was to determine the effects of unilateral versus bilateral subthalamic nucleus (STN) stimulation on quantitative measures of walking and reaching in Parkinson's disease (PD). We used kinematic measures and the Unified Parkinson's Disease Rating Scale (UPDRS) m
## Abstract In Parkinson's disease (PD), levodopa and subthalamic nucleus (STN) stimulation lead to major improvement in motor symptoms. Effects of both treatments on cognition and affective status are less well understood. Motor, cognitive, and affective symptoms may relate to the dysfunctioning o