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Unilateral pulmonary artery occlusion inhibits growth of metastatic sarcoma in the rat lung

✍ Scribed by Hong-Yue Wang; Bruce Ng; Charles Ahrens; Michael Burt

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 368 KB
Volume: 57
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930570309

No coin nor oath required. For personal study only.

✦ Synopsis

Tumors depend on their blood supply for growth. The blood supply to metastatic neoplasia of lung is usually from the pulmonary circulation or both the pulmonary and systemic circulation. The antineoplastic effect of pulmonary artery occlusion was investigated in a rat model of methylcholanthrene-induced metastatic pulmonary sarcoma. Left pulmonary artery ligation was performed on day 7 after tumor inoculation, and animals were sacrificed on day 14. The tumor burden of the left lung decreased 44% when compared with the control group. The survival of non-tumorbearing rats undergoing left pulmonary artery ligation for 24 hours followed by right pneumonectomy after 2 weeks was also studied. No significant lung damage after a period of left pulmonary artery ligation was seen, as evidenced by both survival after contralateral right pneumonectomy and histology. Balloon occlusion of pulmonary artery, together with regional chemotherapy for patients with lung metastases, may warrant investigation. 0 1 9 4 Wiley-Liss, Inc.

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