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Unilateral intraputamenal glial cell line–derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal

✍ Scribed by Slevin, John T.; Gash, Don M.; Smith, Charles D.; Gerhardt, Greg A.; Kryscio, Richard; Chebrolu, Himachandra; Walton, Ashley; Wagner, Renee; Young, A. Byron

Book ID: 125438849
Publisher: American Association of Neurological Surgeons
Year: 2007
Tongue: English
Weight: 335 KB
Volume: 106
Category: Article
ISSN: 1933-0693
DOI: 10.3171/jns.2007.106.4.614

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✍ Niklas Lindgren; Rehana K. Leak; Kirsten M. Carlson; Amanda D. Smith; Michael J. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 851 KB

## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN