Prediction of drug tissue to plasma conc
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Rasmus Jansson; Ulf Bredberg; Michael Ashton
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Article
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2008
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John Wiley and Sons
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English
β 186 KB
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One of the drug specific parameters needed in physiologically based pharmacokinetic (PBPK) models is the tissue to plasma drug concentration ratios (K(p) values). The aim of this study was to develop an empirical method for predicting K(p) values using a preclinically determined in vivo volume of di