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Uniform distributions in a class of convex polyhedrons with applications to drug combination studies

✍ Scribed by Guo-Liang Tian; Hong-Bin Fang; Ming Tan; Hong Qin; Man-Lai Tang


Book ID
108185590
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
902 KB
Volume
100
Category
Article
ISSN
0047-259X

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One of the drug specific parameters needed in physiologically based pharmacokinetic (PBPK) models is the tissue to plasma drug concentration ratios (K(p) values). The aim of this study was to develop an empirical method for predicting K(p) values using a preclinically determined in vivo volume of di