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Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum

✍ Scribed by Neil Kaplowitz; Cheng Ji

Book ID
108951057
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
98 KB
Volume
21
Category
Article
ISSN
0815-9319

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ