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Unexpected NC bond fission of fused N-alkylbenzimidazolium salts. A new approach to pyrido[1,2-a]- or pyridazino[1,6-a]benzimidazoles

✍ Scribed by Jorge G. Siro; Joaquín Pastor; JoséL. García-Navío; Juan J. Vaquero; Julio Alvarez-Builla

Book ID
104208314
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
345 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

The reaction of N-carboxymethylpyrido[1,2-a]-and pyridazino[1,6-a]benzimidazolium salts with thionyl chloride resulted in an N-C bond fission, yielding the corresponding pyrido[ 1,2-a]and pyridazino[1,6-a]benzimidazoles. A similar dealkylation process was observed when analogous N-propargylic derivatives were treated with Cu (II) acetate.

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