✦ LIBER ✦

Unexpected host range of hepatitis C virus replicons

✍ Scribed by Ralf Bartenschlager

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 151 KB
Volume: 39
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.20122

No coin nor oath required. For personal study only.

✦ Synopsis

The hepatitis C virus (HCV) pandemic affects the health of more than 170 million people and is the major indication for orthotopic liver transplantations. Although the human liver is the primary site for HCV replication, it is not known if extrahepatic tissues are also infected by the virus nor if nonprimate cells are permissive for RNA replication. Because HCV exists as a quasispecies, it is conceivable that a viral population may include variants that can replicate in different cell types and other species. We have tested this hypothesis and found that subgenomic HCV RNA can replicate in mouse hepatoma and nonhepatic human epithelial cells. Replicons isolated from these cell lines carry new mutations that could be involved in the control of tropism of the virus. Our results demonstrated that translation and RNA-directed RNA replication of HCV do not depend on hepatocyte or primate-specific factors. Moreover, our results could open the path for the development of animal models for HCV infection.

📜 SIMILAR VOLUMES

Host response to hepatitis C virus

✍ Sabine Mihm 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB 👁 1 views

We read with interest a paper by Kudo et al. published in a recent issue of HEPATOLOGY that compared the predictive power between Japan Integrated Staging (JIS) system and Cancer of the Liver Italian Program (CLIP) system in a large patient cohort with hepatocellular carcinoma (HCC). 1 The authors c

Hepatitis C virus entry into host cells

✍ F. Helle; J. Dubuisson 📂 Article 📅 2007 🏛 Springer 🌐 English ⚖ 848 KB

Host range studies of GB virus-B hepatit

Host range studies of GB virus-B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees

✍ Jens Bukh; Carl L. Apgar; Sugantha Govindarajan; Robert H. Purcell 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB

## Abstract GB virus‐B (GBV‐B) is a member of the Flaviviridae family of viruses. This RNA virus causes acute resolving hepatitis in experimentally infected tamarins, but its natural host remains unknown. GBV‐B and a related virus, GBV‐A, were recovered from serum containing the “GB agent,” which w

Host dependent variation of hepatitis C

Host dependent variation of hepatitis C virus: phylogenetic analyses

✍ S. Maekawa; N. Enomoto; M. Kurosaki; F. Marumo; C. Sato 📂 Article 📅 1995 🏛 Springer Vienna 🌐 English ⚖ 832 KB

Host cell responses induced by hepatitis

Host cell responses induced by hepatitis C virus binding

✍ Xinhua Fang; Mirjam B. Zeisel; Jochen Wilpert; Bettina Gissler; Robert Thimme; C 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 581 KB

Initiation of hepatitis C virus (HCV) infection is mediated by docking of the viral envelope to the hepatocyte cell surface membrane followed by entry of the virus into the host cell. Aiming to elucidate the impact of this interaction on host cell biology, we performed a genomic analysis of the host

Host neutralizing responses and pathogen

Host neutralizing responses and pathogenesis of hepatitis C virus infection

✍ Mirjam B. Zeisel; François-Loïc Cosset; Thomas F. Baumert 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 489 KB 👁 2 views