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Unexpected complexity of the Wnt gene family in a sea anemone

✍ Scribed by Kusserow, Arne; Pang, Kevin; Sturm, Carsten; Hrouda, Martina; Lentfer, Jan; Schmidt, Heiko A.; Technau, Ulrich; von Haeseler, Arndt; Hobmayer, Bert; Martindale, Mark Q.; Holstein, Thomas W.

Book ID: 118675828
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 344 KB
Volume: 433
Category: Article
ISSN: 0028-0836
DOI: 10.1038/nature03158

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## Abstract Anthopleurin‐A (AP‐A) is a member of a family of sea anemone‐derived polypeptides that interact with sodium channels in a voltage‐dependent manner, producing a positive inotropic effect on the mammalian heart. There has been considerable interest in this molecule as a lead compound for